Antidiabetic coumarin and cyclitol compounds from Peucedanum japonicum.
Arch Pharm Res
; 27(12): 1207-10, 2004 Dec.
Article
em En
| MEDLINE
| ID: mdl-15646792
ABSTRACT
The antidiabetic activity-guided fractionation and isolation of the 80% EtOH extracts from Peucedani Radix (Peucedanum japonicum, Umbelliferae) led to the isolation and characterization of a coumarin and a cyclitol as active principles, that is, peucedanol 7-O-beta-D-glucopyranoside (1) and myo-inositol (2). Their structures were identified by spectroscopic methods. Compound 1 showed 39% inhibition of postprandial hyperglycemia at 5.8 mg/kg dose, and compound 2 also significantly inhibited postprandial hyperglycemia by 34% (P<0.05).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apiaceae
/
Cumarínicos
/
Hipoglicemiantes
Limite:
Animals
Idioma:
En
Revista:
Arch Pharm Res
Ano de publicação:
2004
Tipo de documento:
Article