Dynamics of pruning in simulated large-scale spiking neural networks.
Biosystems
; 79(1-3): 11-20, 2005.
Article
em En
| MEDLINE
| ID: mdl-15649585
ABSTRACT
Massive synaptic pruning following over-growth is a general feature of mammalian brain maturation. This article studies the synaptic pruning that occurs in large networks of simulated spiking neurons in the absence of specific input patterns of activity. The evolution of connections between neurons were governed by an original bioinspired spike-timing-dependent synaptic plasticity (STDP) modification rule which included a slow decay term. The network reached a steady state with a bimodal distribution of the synaptic weights that were either incremented to the maximum value or decremented to the lowest value. After 1x10(6) time steps the final number of synapses that remained active was below 10% of the number of initially active synapses independently of network size. The synaptic modification rule did not introduce spurious biases in the geometrical distribution of the remaining active projections. The results show that, under certain conditions, the model is capable of generating spontaneously emergent cell assemblies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Potenciais de Ação
/
Rede Nervosa
Idioma:
En
Revista:
Biosystems
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
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