Post-transfusion purpura.
Curr Hematol Rep
; 4(2): 154-9, 2005 Mar.
Article
em En
| MEDLINE
| ID: mdl-15720966
ABSTRACT
Post-transfusion purpura (PTP) is a rare bleeding disorder caused by alloantibodies specific to platelet antigens. The antibody against the human platelet alloantigen (HPA)-1a is responsible for most of the cases. The majority of affected patients are multiparous women who presumably have been previously sensitized during pregnancy. Blood transfusions rarely have been implicated as the primary cause for alloimmunization in PTP. Thrombocytopenia is usually severe and resolves spontaneously within several weeks. However, patients may develop severe if not fatal bleeding during the course of this disease. The diagnosis is confirmed by demonstrating that the patient's serum contains antibodies to platelet-specific antigens. Treatments for PTP include intravenous immunoglobulin, corticosteroids, and plasmapheresis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Púrpura
/
Reação Transfusional
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Curr Hematol Rep
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos