Consensual immunity: success-driven development of T-helper-1 and T-helper-2 responses.
Nat Rev Immunol
; 5(3): 251-60, 2005 03.
Article
em En
| MEDLINE
| ID: mdl-15738955
ABSTRACT
Non-germline-encoded T- and B-cell receptors allow humans to effectively deal with rapidly mutating pathogens. Here, we argue that, in addition to determining the antigenic specificity of immune responses, the same receptor systems can also regulate the T-helper-1/T-helper-2 profile of immunity. Such a mechanism--based on feedback from distinct effector cells to dendritic cells, rather than on instruction from pathogens--uses the effectiveness of particular effector cells at targeting and destroying a pathogen as a reliable, experience-based criterion to induce and maintain the appropriately polarized response.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Th2
/
Células Th1
/
Imunidade
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Nat Rev Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos