The relationship between extracellular matrix vesicles and calcospherities in primary mineralization of neoplastic bone tissue. TEM and SEM studies on osteosarcoma.
Virchows Arch A Pathol Anat Histol
; 382(1): 1-9, 1979 May 14.
Article
em En
| MEDLINE
| ID: mdl-157592
ABSTRACT
Primary mineralization in neoplastic tissue was studied in osteosarcoma, correlating observations obtained by SEM to those found with TEM. The process is characterized by extracellular matrix vesicles, distributed in the matrix between the forming neoplastic cells and the calcifying fronts. The occurrence of osmiophilic material and solitary hydroxyapatite crystals within the vesicles is followed by accumulation of apatite crystals, disappearance of the vesicular membrane and formation of calcospherites and calcified fronts. The process described here in neoplastic tissue is essentially similar to primary calcification in normal calcified tissues.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ósseas
/
Osteossarcoma
/
Espaço Extracelular
Limite:
Humans
Idioma:
En
Revista:
Virchows Arch A Pathol Anat Histol
Ano de publicação:
1979
Tipo de documento:
Article