Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy.
Chem Commun (Camb)
; (14): 1860-2, 2005 Apr 14.
Article
em En
| MEDLINE
| ID: mdl-15795767
The enantioselective synthesis of a simplified eleutherobin analogue by ring closing metathesis (RCM) of the 2,9-divinyl-substituted tetrahydro-oxonin is described; the analogue and an advanced intermediate revealed microtubule stabilising properties in the micromolar range.
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MEDLINE
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Diterpenos
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2005
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Article