Intrathecal application of cyproheptadine impairs locomotion in intact rats.
Neurosci Lett
; 381(1-2): 16-20, 2005.
Article
em En
| MEDLINE
| ID: mdl-15882782
ABSTRACT
In intact adult rats, cyproheptadine, a 5-HT2 antagonist, administered intrathecally at the midlumbar segments was found to impair hindlimb locomotor movements during overground locomotion. These effects were dose-dependent; they varied from transient complete hindlimb paraplegia seen at doses of 300 microg/20 microl, to short-lasting trunk instability at doses of 100 microg/20 microl. After the return of overground locomotion, transient abduction of one of the hindlimbs was observed in some animals. These findings demonstrate that the blockade of 5-HT2 receptors affects locomotion in intact rats. Our results provide support for the hypothesis of serotonergic involvement in rat locomotion, which, so far, has been based mainly on the effects of 5-HT2 agonists on the recovery of locomotion in spinal rats.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Ciproeptadina
/
Antagonistas do Receptor 5-HT2 de Serotonina
/
Membro Posterior
/
Locomoção
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Polônia