Synthesis of 5'-triphosphate mimics (P3Ms) of 3'-azido-3',5'-dideoxythymidine and 3',5'-dideoxy-5'-difluoromethylenethymidine as HIV-1 reverse transcriptase inhibitors.
Nucleosides Nucleotides Nucleic Acids
; 24(3): 179-89, 2005.
Article
em En
| MEDLINE
| ID: mdl-15892257
ABSTRACT
3'-Azido-3',5-dideoxythymidine 5'-phosphonate and 3',5'-dideoxy-5'-difluoromethylenethymidine 5'-phosphonate were prepared by multistep syntheses. The nucleoside 5'-phosphonates were converted to their triphosphates and triphosphate mimics (P3Ms) containing beta,gamma-difluoromethylene, beta,gamma-dichloromethylene, or beta,gamma-imodo by condensation with pyrophosphate or pyrophosphate mimics, respectively. Inhibition of HIV-1 reverse transcriptase by the nucleoside P3Ms is briefly discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timidina
/
Nucleotídeos de Timina
/
Zidovudina
/
Mimetismo Molecular
/
Inibidores da Transcriptase Reversa
/
Transcriptase Reversa do HIV
Idioma:
En
Revista:
Nucleosides Nucleotides Nucleic Acids
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos