Your browser doesn't support javascript.
loading
Regression of ocular adnexal lymphoma after Chlamydia psittaci-eradicating antibiotic therapy.
Ferreri, Andrés J M; Ponzoni, Maurilio; Guidoboni, Massimo; De Conciliis, Carlo; Resti, Antonio Giordano; Mazzi, Benedetta; Lettini, Antonia Anna; Demeter, Judit; Dell'Oro, Stefania; Doglioni, Claudio; Villa, Eugenio; Boiocchi, Mauro; Dolcetti, Riccardo.
Afiliação
  • Ferreri AJ; Department of Radiochemotherapy, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy. andres.ferreri@hsr.it
J Clin Oncol ; 23(22): 5067-73, 2005 Aug 01.
Article em En | MEDLINE | ID: mdl-15968003
PURPOSE: Some infectious agents contributing to lymphomagenesis have been considered targets for new therapeutic strategies. Chlamydia psittaci DNA has been detected in 80% of ocular adnexal lymphomas. The present pilot study was carried out to assess whether C psittaci-eradicating antibiotic therapy is associated with tumor regression in ocular adnexal lymphomas. PATIENTS AND METHODS: Nine patients with C psittaci-positive marginal-zone B-cell lymphoma of the ocular adnexa at diagnosis or relapse were treated with doxycycline 100 mg, bid orally, for 3 weeks. The presence of C psittaci DNA in peripheral-blood mononuclear cells (PBMCs) was also assessed before and after treatment in seven patients. Objective lymphoma regression was assessed 1, 3, and 6 months after therapy conclusion and every 6 months during follow-up. RESULTS: All patients completed antibiotic therapy with excellent tolerability. At 1 month from doxycycline assumption, chlamydial DNA was no longer detectable in PBMCs of all four positive patients. Objective response was complete in two patients, partial response (> 50%) was observed in two patients, and minimal response (< 50%) was observed in three patients. Duration of response in the seven responders was 12+, 29+, 31+, 8+, 7+, 2+, and 1+ months, respectively. CONCLUSION: C psittaci-eradicating antibiotic therapy with doxycycline is followed by objective response in patients with ocular adnexal lymphoma, even after multiple relapses of the disease. A confirmatory, large, phase II trial is warranted to confirm whether this fast, cheap, and well-tolerated therapy could replace other more aggressive strategies as first-line treatment against ocular adnexal lymphomas.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psitacose / Chlamydophila psittaci / Linfoma de Células B / Doxiciclina / Neoplasias Oculares / Antibacterianos Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Oncol Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Itália
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psitacose / Chlamydophila psittaci / Linfoma de Células B / Doxiciclina / Neoplasias Oculares / Antibacterianos Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Oncol Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Itália