Error-prone repair and translesion synthesis III: the activation of UmuD (or less is more).
DNA Repair (Amst)
; 4(9): 1047-8, 1058-9, 2005 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-15985388
ABSTRACT
Following DNA damage to Escherichia coli bacteria, RecA protein is activated by binding to single stranded DNA and cleaves its own gene repressor (LexA protein). Two papers from Graham Walker's laboratory showed that several bacterial genes in addition to RecA are repressed by the LexA repressor and are inducible following DNA damage [C.J. Keyon, G.C. Walker, DNA-damaging agents stimulate gene expression at specific loci in Escherichia coli, in Proceedings of the National Academy of Sciences of the United States of America 77, 1980, pp. 2819--2823] and predicted that one of them (UmuD) might itself be subject to activation by a further cleavage reaction involving activated RecA protein [K.L. Perry, S.J. Elledge, B.B. Mitchell, L. Marsh, G.C. Walker, umuD,C and mucA,B operans whose products are required for UV light- and chemical-induced mutagenesis UmuD, MucA, and LexA proteins share homology, in Proceedings of the National Academy of Sciences of the United States of America 82, 1985, pp. 4331--4335]. The processed form of UmuD, termed UmuD', later proved to be a subunit of DNA polymerase V, a key enzyme involved in translesion synthesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recombinases Rec A
/
Proteínas de Bactérias
/
Mutagênese
/
Escherichia coli
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
DNA Repair (Amst)
Assunto da revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Reino Unido