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Development of gamma delta T-cell subsets from fetal hematopoietic stem cells.
Ikuta, K; Kina, T; MacNeil, I; Uchida, N; Peault, B; Chien, Y H; Weissman, I L.
Afiliação
  • Ikuta K; Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305.
Ann N Y Acad Sci ; 651: 21-32, 1992 May 04.
Article em En | MEDLINE | ID: mdl-1599125
Hematopoietic stem cells (HSC) were isolated from mouse fetus, and their developmental potential was compared with adult HSC. Donor-derived V gamma 3+T cells were detected in fetal thymic lobes, repopulated in vitro with fetal liver HSC, but not in those with adult bone marrow HSC. Single clonogenic fetal HSC gave rise to thymic progeny that include V gamma 3+, other gamma delta+, and alpha beta+ T cells. No V gamma 3+ T cells were detected in adult thymus injected intrathymically with either fetal or adult HSC. These results support a hypothesis that only fetal HSC have the capacity to differentiate into V gamma 3+ T cells in the fetal thymic microenvironment, and that the developmental potential of HSC may change during ontogeny.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Timo / Células-Tronco Hematopoéticas / Receptores de Antígenos de Linfócitos T / Subpopulações de Linfócitos T Limite: Animals Idioma: En Revista: Ann N Y Acad Sci Ano de publicação: 1992 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Timo / Células-Tronco Hematopoéticas / Receptores de Antígenos de Linfócitos T / Subpopulações de Linfócitos T Limite: Animals Idioma: En Revista: Ann N Y Acad Sci Ano de publicação: 1992 Tipo de documento: Article