In vivo tissue characterization using magnetic techniques.
Neurol Clin Neurophysiol
; 2004: 85, 2004 Nov 30.
Article
em En
| MEDLINE
| ID: mdl-16012653
ABSTRACT
Among the few non-invasive methods to quantify liver iron deposits, magnetic resonance imaging (MRI) and biomagnetic liver susceptometry (BLS) have been considered the best to evaluate iron overload in the body. This diagnosis is necessary for patients who regularly receive red blood cells transfusion and that have a genetic disorder known as hemochromatosis. In this work, we present the evaluation of the clinical usefulness of MRI and BLS of hepatic tissue to quantify iron deposits in non-transfused and transfused patients. Liver iron evaluation by MRI and BLS were performed in a group of 48 patients. The MRI images weighted in T2 were acquired using multi-slice single-spin-echo (SSE) and single-slice multi-spin-echo (MSE), conducted on a 1.5 T whole body scanner. BLS measurements were performed using an ac superconducting susceptometer based on SQUID. Typically MRI is able to evaluate iron overload in liver as high as 30 mg/g(dry tissue) when using MRI scanners provided with specially designed pulse sequences. For higher iron concentrations susceptibility measurement works better than MRI to evaluate higher iron overloads in the liver, because in this case there is saturation of MRI signal.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Campos Eletromagnéticos
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Fígado
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
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Adult
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Aged
/
Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Neurol Clin Neurophysiol
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Brasil