ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation.
Cell Metab
; 1(2): 121-31, 2005 Feb.
Article
em En
| MEDLINE
| ID: mdl-16054053
ABSTRACT
Here we demonstrate that the ABC transporter ABCG1 plays a critical role in lipid homeostasis by controlling both tissue lipid levels and the efflux of cellular cholesterol to HDL. Targeted disruption of Abcg1 in mice has no effect on plasma lipids but results in massive accumulation of both neutral lipids and phospholipids in hepatocytes and in macrophages within multiple tissues following administration of a high-fat and -cholesterol diet. In contrast, overexpression of human ABCG1 protects murine tissues from dietary fat-induced lipid accumulation. Finally, we show that cholesterol efflux to HDL specifically requires ABCG1, whereas efflux to apoA1 requires ABCA1. These studies identify Abcg1 as a key gene involved in both cholesterol efflux to HDL and in tissue lipid homeostasis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação da Expressão Gênica
/
Colesterol
/
Transportadores de Cassetes de Ligação de ATP
/
Metabolismo dos Lipídeos
/
Lipoproteínas
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Lipoproteínas HDL
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Cell Metab
Assunto da revista:
METABOLISMO
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos