Production of the radioactive antitumoral cisplatin.
Appl Radiat Isot
; 64(2): 178-81, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16099666
ABSTRACT
This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP*, sealed in a cadmium capsule. The irradiation of CDDP covered by cadmium, employing exposure times longer than 2 h, demonstrated good chemical purity and high specific activity. This finding allowed a better detection of in vivo CDDP* and suggests that it may be a good tool for studies of long-term biodistribution of pharmaceutical formulations containing this drug.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Platina
/
Radioisótopos
/
Cisplatino
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Revista:
Appl Radiat Isot
Assunto da revista:
MEDICINA NUCLEAR
/
SAUDE AMBIENTAL
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Brasil