The many phases of anaphase.
Trends Biochem Sci
; 30(10): 559-68, 2005 Oct.
Article
em En
| MEDLINE
| ID: mdl-16126387
ABSTRACT
Anaphase is the stage of the cell cycle in which duplicated chromosomes separate and move towards opposite poles of the cell. Although its chromosome movements have always been viewed as majestic, until recently anaphase lacked obvious landmarks of regulation. The picture has changed with numerous recent studies that have highlighted the raison d'être of anaphase. It is now known to be associated with a series of regulatory pathways that promote a switch from high to low cyclin-dependent kinase activity--an essential feature for proper mitotic exit. The balance between protein phosphorylation and protein dephosphorylation drives and coordinates diverse processes such as chromosome movement, spindle dynamics and cleavage furrow formation. This well-ordered sequence of events is central to successful mitosis.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinases Ciclina-Dependentes
/
Anáfase
/
Mitose
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos