Cytogenetic studies in children with Down syndrome and acute leukemia.
Leuk Res
; 29(11): 1241-6, 2005 Nov.
Article
em En
| MEDLINE
| ID: mdl-16164980
ABSTRACT
The frequency of chromosomal alterations was compared among four children groups those with Down syndrome and acute leukemia (DS/AL), those with acute leukemia (AL), those with only Down syndrome (DS) and healthy children (NC). The frequency of acquired chromosome abnormalities was larger in the AL group, followed by the DS/AL. The gaps and isogaps were more frequent in children with only DS. The polymorphisms of the constitutive heterochromatin were larger in the DS/AL group. These findings appear to imply that more genetic changes are necessary to develop AL in the case of healthy children compared to children with DS.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia
/
Síndrome de Down
/
Análise Citogenética
Tipo de estudo:
Diagnostic_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Leuk Res
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
México