[Effect of large-dosage of 5alpha-reductase inhibitors on the spermatogenesis of male rats].
Zhonghua Nan Ke Xue
; 11(9): 652-4, 2005 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-16209201
ABSTRACT
OBJECTIVE:
To identify the role of 5alpha-reductase in the spermatogenesis of male rats by studying the effect of two 5alpha-reductase inhibitors, Epristeride and Finasteride, on the spermatogenesis in male Sprague-Dawley (SD) rats.METHODS:
Changes in the weight of the testis, serum testosterone and dihydrotestosterone levels, epididymal sperm count, and reproductive function were observed and analyzed after the two 5alpha-reductase inhibitors were administered to male SD rats orally.RESULTS:
The experiment showed that in comparison with control animals, both the two 5alpha-reductase inhibitors 1. suppressed the development of the prostate and reduced the weight of the testis in the experimental groups (P < 0.05); 2. decreased the serum level of dihydrotestosterone and enhanced testosterone; 3. inhibited epididymal sperm count and productive function.CONCLUSION:
High dosages of the 5alpha-reductase inhibitor, Epristeride, can suppress the development of the prostate and reduce the weight of the testis, decrease dihydrotestosterone, and inhibit spermatogenesis and productive function in male rats.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espermatogênese
/
Inibidores de 5-alfa Redutase
/
Androstadienos
Limite:
Animals
Idioma:
Zh
Revista:
Zhonghua Nan Ke Xue
Assunto da revista:
MEDICINA REPRODUTIVA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
China