Enantiomeric separation of 1-phenylethylamine and 1-cyclohexylethylamine in capillary electrophoresis with contactless conductivity detection.
J Chromatogr A
; 1094(1-2): 196-9, 2005 Nov 11.
Article
em En
| MEDLINE
| ID: mdl-16213508
ABSTRACT
Contactless conductivity detection was employed for the detection of the enantiomers of 1-phenylethylamine and 1-cyclohexylethylamine which were separated in capillary electrophoresis with unprecedented high resolutions R(s) of 2.3 and 3.3, respectively, by using a combination of dimethyl-beta-cyclodextrin and the chiral crown ether 18C6H4 as chiral selectors in a citric acid buffer of pH 2.4. The conductivity measurement enabled the direct detection, i.e. without having to derivatize or resort to indirect methods, of all species including the non-UV-absorbing enantiomers of cyclohexylamine. Detection limits of 0.5 microM were achieved and the determination of enantiomeric ratios of up to 991 was found possible.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenetilaminas
/
Eletroforese Capilar
/
Etilaminas
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
J Chromatogr A
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Suíça