Metal ions and oxidative protein modification in neurological disease.
Ann Ist Super Sanita
; 41(2): 143-64, 2005.
Article
em En
| MEDLINE
| ID: mdl-16244388
ABSTRACT
This review highlights the role of oxidative stress and imbalances in metal ion homeostasis in the neurodegenerative diseases Alzheimer's disease and Parkinson's disease and in the progressive demyelinating disease multiple sclerosis. The chemistry and biochemistry of oxidative stress-induced protein damage are first described, followed by the evidence for a pathological role of oxidative stress in these disease states. It is tempting to speculate that free radical oxygen chemistry contributes to pathogenesis in all these conditions, though it is as yet undetermined what types of oxidative changes occur early in the disease, and what types are secondary manifestations of neuronal degeneration.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Estresse Oxidativo
/
Doenças Neurodegenerativas
/
Metais
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Ann Ist Super Sanita
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos