Deinococcus radiodurans - the consummate survivor.
Nat Rev Microbiol
; 3(11): 882-92, 2005 Nov.
Article
em En
| MEDLINE
| ID: mdl-16261171
ABSTRACT
Relatively little is known about the biochemical basis of the capacity of Deinococcus radiodurans to endure the genetic insult that results from exposure to ionizing radiation and can include hundreds of DNA double-strand breaks. However, recent reports indicate that this species compensates for extensive DNA damage through adaptations that allow cells to avoid the potentially detrimental effects of DNA strand breaks. It seems that D. radiodurans uses mechanisms that limit DNA degradation and that restrict the diffusion of DNA fragments that are produced following irradiation, to preserve genetic integrity. These mechanisms also increase the efficiency of the DNA-repair proteins.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Deinococcus
Idioma:
En
Revista:
Nat Rev Microbiol
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos