Gender specific association of CYP2C9*3 with hyperlipidaemia in Chinese.
Br J Clin Pharmacol
; 60(6): 629-31, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16305587
ABSTRACT
AIMS:
To investigate the association of CYP2C9*3 and *6 with hyperlipidaemia in Chinese.METHODS:
Four hundred and seventy-six Chinese participated in the study, including 211 uncomplicated hyperlipidaemic patients and 265 healthy controls. PCR-RFLP was used to identify CYP2C9*3 and *6.RESULTS:
CYP2C9*6 was not detected in this study. The allelic frequency of CYP2C9*3 was 0.039 (95% CI 0.022, 0.056). A nonsignificant difference existed in CYP2C9*3 frequencies between males and females (P = 0.605, OR = 1.194, 95% CI 0.610, 2.336), patients and controls (P = 0.063, OR = 0.506, 95% CI 0.244, 1.049) in the total population. However, in the female group, CYP2C9*3 frequency in patients with hyperlipidaemia was significantly lower than that in controls (P < 0.0001, OR = 0.062, 95% CI 0.008, 0.476).CONCLUSIONS:
The association of CYP2C9*3 with hyperlipidaemia was specific for females in this Chinese population.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidrocarboneto de Aril Hidroxilases
/
Hiperlipidemias
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Br J Clin Pharmacol
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
China