Uncover genetic interactions in Caenorhabditis elegans by RNA interference.
Biosci Rep
; 25(5-6): 299-307, 2005.
Article
em En
| MEDLINE
| ID: mdl-16307378
ABSTRACT
RNA-mediated interference (RNAi) has emerged recently as one of the most powerful functional genomics tools. RNAi has been particularly effective in the nematode worm C. elegans where RNAi has been used to analyse the loss-of-function phenotypes of almost all predicted genes. In this review, we illustrate how RNAi has been used to analyse gene function in C. elegans as well as pointing to some future directions for using RNAi to examine genetic interactions in a systematic manner.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação da Expressão Gênica no Desenvolvimento
/
Interferência de RNA
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Biosci Rep
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Reino Unido