Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys.
Nat Med
; 11(12): 1295-8, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16311604
ABSTRACT
We transplanted kidneys from alpha1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GalT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GalT-KO pigs to humans.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante Heterólogo
/
Animais Geneticamente Modificados
/
Transplante de Rim
/
Rejeição de Enxerto
/
Tolerância Imunológica
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Nat Med
Assunto da revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Canadá