The immune system provides a strong response to even a low exposure to virus.
Clin Immunol
; 119(1): 87-94, 2006 Apr.
Article
em En
| MEDLINE
| ID: mdl-16386960
ABSTRACT
How influenza virus dose affects the size of the immune response has not been clearly documented. Mice were challenged with three doses of influenza virus spanning a 100-fold range. Increasing the viral input dose increased the degree of weight loss observed, the clinical score and eventual mortality. Maximum viral loads increased with viral input and lower doses peaked and declined earlier. The level of the immune response only varied 2-fold and was independent of viral dose with near maximal responses elicited by the lowest dose, as measured by influx of antigen-specific and non-specific leukocytes into the lungs and by influenza antibody titers. We conclude that a strong immune response is mounted to a small dose of virus and curbs the spread of virus early and prevents weight loss whereas larger doses of virus elicit a slightly greater response but the associated disease can overwhelm the host.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Orthomyxoviridae
/
Vírus da Influenza A Subtipo H1N1
/
Imunidade Celular
/
Formação de Anticorpos
Idioma:
En
Revista:
Clin Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos