Identification of a bacterial type III effector family with G protein mimicry functions.
Cell
; 124(1): 133-45, 2006 Jan 13.
Article
em En
| MEDLINE
| ID: mdl-16413487
ABSTRACT
Many bacterial pathogens use the type III secretion system to inject "effector" proteins into host cells. Here, we report the identification of a 24 member effector protein family found in pathogens including Salmonella, Shigella, and enteropathogenic E. coli. Members of this family subvert host cell function by mimicking the signaling properties of Ras-like GTPases. The effector IpgB2 stimulates cellular responses analogous to GTP-active RhoA, whereas IpgB1 and Map function as the active forms of Rac1 and Cdc42, respectively. These effectors do not bind guanine nucleotides or have sequences corresponding the conserved GTPase domain, suggesting that they are functional but not structural mimics. However, several of these effectors harbor intracellular targeting sequences that contribute to their signaling specificities. The activities of IpgB2, IpgB1, and Map are dependent on an invariant WxxxE motif found in numerous effectors leading to the speculation that they all function by a similar molecular mechanism.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Transdução de Sinais
/
Mimetismo Molecular
/
Proteínas rho de Ligação ao GTP
/
Proteínas rac1 de Ligação ao GTP
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos