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Abnormal presence of semimature dendritic cells that induce regulatory T cells in HIV-infected subjects.
Krathwohl, Mitchell D; Schacker, Timothy W; Anderson, Jodi L.
Afiliação
  • Krathwohl MD; Department of Medicine, University of Minnesota, Minneapolis, USA. mitch@rosettastonelabs.com.
J Infect Dis ; 193(4): 494-504, 2006 Feb 15.
Article em En | MEDLINE | ID: mdl-16425128
Dendritic cells (DCs), because they orchestrate the immune response to microbes, represent an ideal target for pathogens attempting to evade the immune system. We hypothesized that interactions between human immunodeficiency virus (HIV) and DCs lead to the development of a semimature state, in which DCs migrate to lymph nodes but induce tolerance in T cells, rather than immunity. We found that lymph nodes from untreated HIV-infected subjects contained an abundance of semimature DCs, the disappearance of which correlated with the initiation of highly active antiretroviral therapy (HAART). Such lymph nodes also contained an abundance of T cells that had a regulatory phenotype and that persisted after HAART. Lymph node DCs from untreated HIV-infected subjects cultured with normal allogeneic T cells induced these T cells to adopt the phenotype of regulatory T cells, an ability that was lost after HAART. We conclude that HIV infection correlates with the presence of semimature DCs that stimulate T cell tolerance rather than immunity. These regulatory T cells may contribute to the lack of effective HIV immune responses.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Dendríticas / Infecções por HIV / HIV-1 / Linfócitos T Reguladores / Fármacos Anti-HIV Limite: Humans Idioma: En Revista: J Infect Dis Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Dendríticas / Infecções por HIV / HIV-1 / Linfócitos T Reguladores / Fármacos Anti-HIV Limite: Humans Idioma: En Revista: J Infect Dis Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Estados Unidos