DNA double-strand break repair: a relentless hunt uncovers new prey.
Cell
; 124(2): 260-2, 2006 Jan 27.
Article
em En
| MEDLINE
| ID: mdl-16439201
ABSTRACT
A major pathway for repair of DNA double-strand breaks is nonhomologous end-joining (NHEJ). In this issue of Cell, and report the discovery of a new NHEJ factor called Cernunnos-XLF. Both groups report that this protein is mutated in a rare inherited human syndrome characterized by severe immunodeficiency, developmental delay, and hypersensitivity to agents that cause DNA double-strand breaks.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Proteínas de Ligação a DNA
/
Reparo do DNA
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos