SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase.
J Med Chem
; 49(3): 1034-46, 2006 Feb 09.
Article
em En
| MEDLINE
| ID: mdl-16451069
ABSTRACT
Novel non-nucleoside inhibitors of the HCV RNA polymerase (NS5b) with sub-micromolar biochemical potency have been identified which are selective for the inhibition of HCV NS5b over other polymerases. The structures of the complexes formed between several of these inhibitors and HCV NS5b were determined by X-ray crystallography, and the inhibitors were found to bind in an allosteric binding site separate from the active site. Structure-activity relationships and structural studies have identified the mechanism of action for compounds in this series, several of which possess drug-like properties, as unique, reversible, covalent inhibitors of HCV NS5b.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Tionas
/
RNA Polimerases Dirigidas por DNA
/
Modelos Moleculares
/
Proteínas não Estruturais Virais
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos