Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread.
J Bacteriol
; 188(4): 1620-7, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16452446
ABSTRACT
The role in virulence of the Shigella flexneri ospB-phoN2 operon has been evaluated. Here we confirm that OspB is an effector and show that apyrase, the product of phoN2, may be a virulence factor, since it is required for efficient intercellular spreading. Apyrase may be important in a deoxynucleoside triphosphate-hydrolyzing activity-independent manner, suggesting that it may act as an interaction partner in the process of IcsA localization.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apirase
/
Shigella flexneri
/
Proteínas de Bactérias
/
Fatores de Transcrição
/
Proteínas de Ligação a DNA
Idioma:
En
Revista:
J Bacteriol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Itália