Brief communication: Successful treatment of pure red-cell aplasia with an anti-interleukin-2 receptor antibody (daclizumab).
Ann Intern Med
; 144(3): 181-5, 2006 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-16461962
ABSTRACT
BACKGROUND:
Pure red-cell aplasia (PRCA) is a rare hematologic disease characterized by anemia, reticulocytopenia, and absence of bone marrow erythroid precursors. Most patients respond to some form of immunosuppressive treatment, but few prospective clinical trials have been performed.OBJECTIVE:
To examine the efficacy of a humanized monoclonal antibody to the interleukin-2 receptor (daclizumab) for treating PRCA.DESIGN:
Pilot study.SETTING:
Federal government research hospital. PATIENTS 15 patients with idiopathic PRCA. INTERVENTION Daclizumab, 1 mg/kg of body weight, every 2 weeks for a total of 5 infusions. Pure red-cell aplasia was defined as transfusion-dependent anemia with a reticulocyte count of 60 x 10(9) cells/L or less and bone marrow showing absent or diminished erythroid precursors. MEASUREMENTS Response to therapy was assessed by transfusion independence, increments in reticulocyte count, and nontransfused hemoglobin.RESULTS:
Daclizumab had little toxicity. Of the 15 patients, 6 patients (40%) responded to treatment. All responders became transfusion-independent and achieved normal or near-normal hemoglobin values and normal reticulocyte counts.LIMITATIONS:
The study was unblinded, and the number of patients was too small to assess drug safety reliably.CONCLUSIONS:
Daclizumab seems safe. Its efficacy in this pilot protocol suggests that expanded study in PRCA and other bone marrow failure syndromes is warranted.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
/
Receptores de Interleucina-2
/
Aplasia Pura de Série Vermelha
/
Imunossupressores
/
Anticorpos Monoclonais
Tipo de estudo:
Guideline
Limite:
Adolescent
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Ann Intern Med
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos