[Thrombocytosis: adverse effect of heparin treatment]. / La thrombocytose: un effet secondaire méconnu de l'héparinothérapie.
Presse Med
; 35(1 Pt 1): 58-60, 2006 Jan.
Article
em Fr
| MEDLINE
| ID: mdl-16462666
ABSTRACT
INTRODUCTION:
Thrombocytosis induced by heparin is rarely reported in the literature. CASE We report here four cases of thrombocytosis, three in patients under treatment for a stable myeloproliferative disorder. Thrombocytosis always regressed when heparin treatment was discontinued, and no thrombotic events occurred.DISCUSSION:
Following several reports suggesting an association between heparin and thrombocytosis, the French adverse drug reporting (pharmacovigilance) network identified 51 cases. Thrombocytosis associated with heparin is probably explained by the latter's potentiation of megakaryocytopoiesis, in particular, by inhibition of platelet factor 4 (PF4). Thrombocytosis is a further reason to monitor platelet counts during heparin treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trombocitose
/
Heparina
/
Fibrinolíticos
/
Anticoagulantes
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
Fr
Revista:
Presse Med
Ano de publicação:
2006
Tipo de documento:
Article