Widespread occurrence of antibodies against circumsporozoite protein and against blood forms of Plasmodium vivax, P. falciparum and P. malariae in Brazilian wild monkeys.
J Med Primatol
; 35(2): 87-96, 2006 Apr.
Article
em En
| MEDLINE
| ID: mdl-16556295
ABSTRACT
BACKGROUND:
A survey of malaria antibodies was carried out over 7 years and a total of 777 serum samples from wild monkeys were collected in three distinct ecological areas of Brazil where autochthonous malaria has been reported the 'Cerrado' (similar to savanna), the Atlantic Forest and the Atlantic Semideciduous Forest.METHODS:
We carried out enzyme-linked immunosorbent assay to investigate the presence of IgG antibodies against peptides of the circumsporozoite protein (CSP) repeat region of 'classic'Plasmodium vivax, P. vivax VK247, human P. vivax-like/P. simiovale, P. brasilianum/P. malariae and P. falciparum. We also carried out immunofluorescence assay with asexual forms of P. vivax, P. malariae and P. falciparum.RESULTS:
The high prevalence of antibodies against CSP in all areas indicates that the monkeys had intense contact with sporozoites from infected anophelines. The immune response against asexual forms of Plasmodium in the monkeys from the Atlantic Forest indicates the development of the infection.CONCLUSIONS:
We discuss the possibility of monkeys being malaria reservoirs in non-endemic areas.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium
/
Malária
/
Doenças dos Macacos
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
J Med Primatol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Brasil