[Multiple isoforms of cyclophilin A associated with human immunodeficiency virus type 1].
Uirusu
; 55(2): 273-9, 2005 Dec.
Article
em Ja
| MEDLINE
| ID: mdl-16557013
ABSTRACT
It is well-known that a peptidyl-prolyl cis-trans isomerase cyclophilin A (CyPA) is incorporated into Human immunodeficiency virus type 1 (HIV-1) particle. The proteome analysis of the purified HIV-1 strain LAV-1 (HIV-1(LAV-1)) reveals that three isoforms of CyPA with an isoelectric point (pI) of 6.00, 6.40, and 6.53 are inside the viral membrane and another isoform with a pI of 6.88 is outside the viral membrane; and that the CyPA isoform with a pI of 6.53 is N-acetylated. The mechanisms that permit the redistribution of CyPA with a pI of 6.88 on the viral surface have not yet been clarified, but it penetrates the viral membrane after budding.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
HIV-1
/
Ciclofilina A
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
Ja
Revista:
Uirusu
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Japão