Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases.
Nat Rev Immunol
; 6(5): 417-23, 2006 May.
Article
em En
| MEDLINE
| ID: mdl-16622477
ABSTRACT
At present, we only have indirect knowledge of the protective role of antigen-specific T cells in human viral infections, and it has been difficult to show a direct correlation between quantitative and qualitative measures of T-cell immunity and virus-associated diseases. However, as described in this Opinion article, recent advances in the characterization of T-cell functions and in the development of standardized T-cell assays have led to the identification of distinct functional signatures of T-cell responses that correlate with levels of viral replication and disease activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus
/
Viroses
/
Subpopulações de Linfócitos T
Tipo de estudo:
Qualitative_research
/
Risk_factors_studies
Limite:
Animals
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Humans
Idioma:
En
Revista:
Nat Rev Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Suíça