The prevalence and clinical implications of c-kit expression in plasma cell myeloma.
Histopathology
; 48(5): 529-35, 2006 Apr.
Article
em En
| MEDLINE
| ID: mdl-16623778
ABSTRACT
AIM:
To evaluate the clinical implications of c-kit (CD117) expression in plasma cell myeloma (PCM). METHODS ANDRESULTS:
We first evaluated the reliability of immunohistochemistry in assessing c-kit expression by comparing the results with those obtained by flow cytometry and gene expression arrays in 22 PCM and in 10 PCM cell lines. Immunohistochemical results showed a perfect concordance with those of flow cytometry; likewise, immunohistochemical and gene expression data were also concordant in all but one PCM and cell lines analysed. Then, we investigated the clinical implications of c-kit immunoreactivity in bone marrow biopsies of 85 PCM patients with a mean follow-up of 41 months. C-kit immunoreactivity was detected in 24 (28.2%) of the 85 cases and it was significantly associated with a high microvessel density, but not with traditional clinicopathological characteristics or with survival.CONCLUSIONS:
Our findings suggest that immunohistochemistry is a reliable indicator of c-kit gene expression and reinforce the notion that approximately one-third of PCM express high levels of c-kit. The lack of association with traditional clinicopathological parameters and patient survival suggests that c-kit expression may not be an adjunct in predicting the clinical course of the disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Proto-Oncogênicas c-kit
/
Mieloma Múltiplo
Tipo de estudo:
Prevalence_studies
/
Prognostic_studies
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Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Histopathology
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Itália