Differential regulation of apical and basal iodide transporters in the thyroid by thyroglobulin.
J Endocrinol
; 189(2): 247-55, 2006 May.
Article
em En
| MEDLINE
| ID: mdl-16648292
ABSTRACT
We have shown that thyroglobulin (Tg) is a potent autocrine regulator of thyroid-specific gene expression, and proposed that the accumulated follicular Tg within the colloid is a major factor in determining follicular function. In the present report, we examined the effect of Tg on the action of TSH/cAMP and iodine with special focus on the regulation of basolateral and apical iodide transporters; the sodium/iodide symporter (NIS) and the pendred syndrome gene (PDS) by Tg. We show that expression of NIS and PDS are differentially regulated by Tg concentration and exposure time. In addition, we found that PDS gene was induced by TSH/cAMP and iodide in the presence of Tg. Based on these results, we propose a model for the physiological turnover of follicular function that is dynamically regulated by Tg.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Tireoglobulina
/
Regulação da Expressão Gênica
/
Simportadores
Limite:
Animals
Idioma:
En
Revista:
J Endocrinol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos