Therapeutic potential of folate uptake inhibition in Plasmodium falciparum.
Trends Parasitol
; 20(3): 109-12, 2004 Mar.
Article
em En
| MEDLINE
| ID: mdl-16676416
ABSTRACT
Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Pirimetamina
/
Sulfadoxina
/
Probenecid
/
Antagonistas do Ácido Fólico
/
Antimaláricos
Limite:
Animals
Idioma:
En
Revista:
Trends Parasitol
Assunto da revista:
PARASITOLOGIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Quênia