CD28-CD57+ T cells predominate in CD8 responses to glatiramer acetate.
J Neuroimmunol
; 178(1-2): 117-29, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-16837065
ABSTRACT
Human T cells adopt a CD28-CD57+ phenotype in chronic viral infections and this has been hypothesized to result from continuous stimulation, however this phenotype may be due to direct viral effects on T cells. Employing MS patients before and after chronic in vivo administration of the antigen glatiramer acetate (GA) we examine this hypothesis. Pre-treatment glatiramer acetate-specific CD8 T cells were CD57-Perforin-. This changed to a predominantly CD28-CD57+Perforin+ response after administration of this drug. This phenotype was only observed after chronic stimulation and not in a recall response to mumps. The relevance to GA's mechanism of action is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Subpopulações de Linfócitos T
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Antígenos CD28
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Linfócitos T CD8-Positivos
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Imunossupressores
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Esclerose Múltipla
Limite:
Adult
/
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos