t(8;14)(q24;q32) in two patients with CD10-negative primary thyroid diffuse large B-cell lymphoma.
Leuk Res
; 31(5): 707-11, 2007 May.
Article
em En
| MEDLINE
| ID: mdl-16887184
ABSTRACT
Diffuse large B-cell lymphoma (DLBCL) with the 8q24 translocation is occasionally seen in the gastrointestinal tract, but has rarely been reported in the thyroid gland. We experienced two cases of primary thyroid DLBCL having t(8;14)(q24;q32). The immunophenotype and karyotype of Case 1 (66-year-old female) and Case 2 (70-year-old female) were CD10-, CD20+, BCL-2+/add(13)(q34), t(8;14)(q24;q32) and CD10-, CD20-, CD79a+, BCL-2-/t(8;14)(q24;q32), respectively. Although long-term complete remission could be achieved in both of our patients by conventional chemotherapy with/without radiation therapy, accumulation of further such cases is necessary to develop a standard treatment protocol and also to elucidate the pathogenesis of t(8;14)(q24;q32)-positive primary thyroid DLBCL.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
/
Cromossomos Humanos Par 8
/
Cromossomos Humanos Par 14
/
Neoplasias da Glândula Tireoide
/
Linfoma de Células B
/
Linfoma Difuso de Grandes Células B
Tipo de estudo:
Guideline
Limite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Leuk Res
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Japão