Characterization of monoclonal antibodies against the p17 core protein of the human immunodeficiency virus 1.
J Immunol Methods
; 128(2): 165-75, 1990 Apr 17.
Article
em En
| MEDLINE
| ID: mdl-1691236
ABSTRACT
Five mouse hybridomas which produce monoclonal antibodies against the p17 core protein of HIV-1 have been isolated. Cross-competition assays and mapping with synthetic peptides demonstrate that two closely related epitopes are identified by these antibodies. Directed against two neighbouring peptides at the carboxy-terminal end of the molecule, they can be used for the selective detection of p17 polypeptide in a viral extract or in an infected cell lysate by a solid-phase sandwich enzyme immunoassay.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Antígenos HIV
/
HIV-1
/
Anticorpos Monoclonais
/
Anticorpos Antivirais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Immunol Methods
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Bélgica