Carrageenan/MIV-150 (PC-815), a combination microbicide.
Sex Transm Dis
; 34(1): 9-14, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-16924181
ABSTRACT
OBJECTIVE:
The objective of this article is to study the effect of PC-815, a novel combination microbicide containing carrageenan and the nonnucleoside reverse transcriptase inhibitor (NNRTI) MIV-150, in blocking HIV-1 and HIV-2 infections in vitro as compared with Carraguard alone. GOAL The goal of this study was to develop a combination microbicide that is more efficacious than Carraguard against HIV-1 and HIV-2. STUDYDESIGN:
The microtiter syncytial assay was used to evaluate 1) the antiviral and virucidal activity of MIV-150 against HIV-1MN; 2) the additive effect of MIV-150 when combined with carrageenan; and 3) a possible interference of seminal fluid in the antiviral activity of these compounds.RESULTS:
MIV-150 effectively inactivated free virus. Combination of MIV-150 and Carraguard demonstrated an additive antiviral effect. Seminal fluid had no effect on the antiviral activity of MIV-150 or Carraguard. The average concentration that blocks 50% of infection (EC50) for PC-815 was approximately 10 times stronger than Carraguard for the different clinical isolates used in the study.CONCLUSION:
Theoretically, PC-815 is likely to be a more efficacious microbicide than Carraguard.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Ureia
/
Carragenina
/
Inibidores da Transcriptase Reversa
/
Chondrus
/
Fitoterapia
/
Anti-Infecciosos
Limite:
Humans
/
Male
Idioma:
En
Revista:
Sex Transm Dis
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos