Multicolor-FISH applied to resolve complex chromosomal changes in a case of T-ALL (FAB L2).
Cytogenet Genome Res
; 114(3-4): 270-3, 2006.
Article
em En
| MEDLINE
| ID: mdl-16954665
ABSTRACT
We report on a patient with a clinically diagnosed acute lymphoblastic leukemia (ALL) with partial unrecorded complex translocation events especially involving chromosomes 5, 9 and 18. At the GTG-band level the karyotype was abnormal in 20% of the analyzed cells. The complex karyotype was studied in more detail by spectral karyotyping (SKY) and multicolor banding (MCB) to characterize it in more detail. Thus, the karyotype could be described very accurately and in summary three different clones were detected, reflecting a high rate of karyotypic evolution in this patient.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia-Linfoma de Células T do Adulto
/
Aberrações Cromossômicas
/
Hibridização in Situ Fluorescente
Limite:
Adolescent
/
Humans
/
Male
Idioma:
En
Revista:
Cytogenet Genome Res
Assunto da revista:
GENETICA
Ano de publicação:
2006
Tipo de documento:
Article