Pulmonary TB and NTM lung disease: comparison of characteristics in patients with AFB smear-positive sputum.
Int J Tuberc Lung Dis
; 10(9): 1001-7, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-16964791
ABSTRACT
OBJECTIVE:
To compare the clinical and radiographic features of pulmonary tuberculosis (PTB) and non-tuberculous mycobacteria (NTM) lung disease in patients with acid-fast bacilli (AFB) positive sputum specimens.DESIGN:
The initial clinical and radiographic features of 229 PTB patients were compared with those of 70 patients with NTM lung disease. The most commonly involved organisms in the NTM lung disease cases were Mycobacterium avium complex (n = 38, 54%) and M. abscessus (n = 26, 37%).RESULTS:
Clinical and radiographic findings that were more common in patients with NTM lung disease than in PTB patients were older age (P < 0.001), non-smoker (P < 0.001), history of previous TB treatment (P < 0.001), absence of pleural effusion (P = 0.017), involvement of middle and/or lower lung zones (P = 0.007), and bilateral disease (P = 0.005). Multivariate analysis showed that older age (> or = 40 years), non-smoker, previous TB treatment, absence of pleural effusion and involvement of middle and/or lower lung zones were significant independent predictors for NTM lung disease.CONCLUSIONS:
There is considerable overlap in the clinical and radiographic appearances of PTB and NTM lung disease. The isolation and identification of causative organisms are mandatory for a correct diagnosis in patients with AFB-positive sputum specimens.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Escarro
/
Tuberculose Pulmonar
/
Pneumopatias
/
Infecções por Mycobacterium não Tuberculosas
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Tuberc Lung Dis
Ano de publicação:
2006
Tipo de documento:
Article