Quantitation of crystalline material within a liquid vehicle using 1H/19F CP/MAS NMR.
J Pharm Sci
; 96(2): 264-7, 2007 Feb.
Article
em En
| MEDLINE
| ID: mdl-17051585
ABSTRACT
A method to detect and quantify a small amount crystalline material within a liquid solution of solubilized material is described. 19F CP-MAS ssNMR was investigated as a technique to detect low levels (0.2 mg/g) of crystalline sodium (2R)-7-{3-[2-chloro-4-(2,2,2-trifluoroethoxy)phenoxy]propoxy}-2-methyl-3,4-dihydro-2H-chromane-2-carboxylate (I) within a solid mixture (with microcrystalline cellulose) and a slurry with a liquid vehicle (capric and caprylic acid triglycerides). The results demonstrate that the area of the 19F CP/MAS signal obtained in 25 min at 25 degrees C is linearly dependent (R2=0.997) on the mass of I within the ssNMR rotor. Slopes of CP-MAS peak area versus mass of I in the rotor were nearly identical for the solid mixture and slurry suspension. Signal-to-noise ratio for the low potency slurry suggest detection and quantitation of 0.1 mg of crystalline I in the rotor, corresponding to 2 mg/g of crystalline material within the slurry suspension.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Éteres Fenílicos
/
Polietilenoglicóis
/
Triglicerídeos
/
Benzopiranos
/
Espectroscopia de Ressonância Magnética
/
Celulose
Idioma:
En
Revista:
J Pharm Sci
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos