TCRgamma silencing during alphabeta T cell development depends upon pre-TCR-induced proliferation.
J Immunol
; 177(9): 6038-43, 2006 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-17056529
ABSTRACT
During thymus development, immature T cells become committed to two distinct lineages based upon expression of alphabeta or gammadelta TCR. In the alphabeta lineage, developing thymocytes progressively extinguish transcription of the TCRgamma genes by a poorly understood process known as gamma silencing. We show that alphabeta lineage thymocytes in mice lacking a functional pre-TCR undergo limited proliferation and fail to silence TCRgamma genes during development. Stimulation of pre-TCR-deficient immature thymocytes with anti-CD3 Abs does not directly down-regulate TCRgamma transcription but restores TCRgamma silencing following proliferation. Collectively our data reveal an important role for pre-TCR induced proliferation in activating the TCRgamma silencer in alphabeta lineage thymocytes, a process that may reinforce alphabeta or gammadelta lineage commitment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timo
/
Subpopulações de Linfócitos T
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Receptores de Antígenos de Linfócitos T gama-delta
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Receptores de Antígenos de Linfócitos T alfa-beta
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Inativação Gênica
Limite:
Animals
Idioma:
En
Revista:
J Immunol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Suíça