Expression of androgen, oestrogen alpha and beta, and progesterone receptors in the canine prostate: differences between normal, inflamed, hyperplastic and neoplastic glands.
J Comp Pathol
; 136(1): 1-8, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17078963
ABSTRACT
The expression of receptor for androgen (AR), oestrogen alpha and beta (ERalpha and ERbeta) and progesterone (PR) was examined immunohistochemically in canine prostate specimens (normal, hyperplastic, inflamed [prostatitis] or neoplastic). AR immunolabelling was seen in 100% of epithelial cells of normal and hyperplastic tissue, the corresponding figures for inflamed and carcinomatous tissue being 74% and 65%, respectively. ERalpha labelling was seen in 85% of epithelial cells in normal prostate glands, the corresponding figures for hyperplastic, inflamed and neoplastic glands being 35%, 22% and 12%, respectively. ERbeta labelling was seen in 85% of epithelial cells of normal glands and in about 70% of such cells in glands showing pathological changes. On the other hand, PR expression (weak) in normal glands was observed in fewer epithelial cells (44%) than in hyperplastic (70%), inflamed (62%) or neoplastic (64%) glands.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Próstata
/
Hiperplasia Prostática
/
Neoplasias da Próstata
/
Prostatite
/
Receptores Androgênicos
/
Receptores de Progesterona
/
Receptor alfa de Estrogênio
/
Receptor beta de Estrogênio
/
Doenças do Cão
/
Cães
Limite:
Animals
Idioma:
En
Revista:
J Comp Pathol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Espanha