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Late thrombosis of drug-eluting stents after discontinuation of clopidogrel: report of two cases and review of the literature.
Chrissoheris, Michael P; Mruthyunjayanna, Vikram; Donohue, Thomas J.
Afiliação
  • Chrissoheris MP; Cardiology Fellow, Hospital of Saint Raphael, New Haven, USA.
Conn Med ; 70(8): 485-90, 2006 Sep.
Article em En | MEDLINE | ID: mdl-17089804
Thrombosis of intracoronary stents is a major complication associated with significant morbidity and mortality. Of concern are case reports of late (more than six months from deployment) drug-eluting stent thrombosis temporally associated with discontinuation of antiplatelet therapy and when stent endothelialization was presumed to be complete. In certain patients it appears that vascular healing at the stented segments is incomplete with increased susceptibility to late thrombosis. We report two cases of late stent thrombosis occuring more than one year after stent deployment and within weeks of discontinuation of clopidogrel. A review of the literature is presented to identify clinical and angiographic predictors of increased risk.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Trombose Coronária / Ticlopidina / Inibidores da Agregação Plaquetária / Stents / Infarto do Miocárdio Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Aged80 / Humans / Male / Middle aged Idioma: En Revista: Conn Med Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Trombose Coronária / Ticlopidina / Inibidores da Agregação Plaquetária / Stents / Infarto do Miocárdio Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Aged80 / Humans / Male / Middle aged Idioma: En Revista: Conn Med Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Estados Unidos