Manic behaviour induced by deep-brain stimulation in Parkinson's disease: evidence of substantia nigra implication?
J Neurol Neurosurg Psychiatry
; 77(12): 1363-6, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-17110749
ABSTRACT
We report the case of a patient who had benefited from bilateral subthalamic nucleus deep brain stimulation for Parkinson's disease and who presented acute and reproducible manic behaviour when stimulated mainly in the substantia nigra. A positron emission tomography scan showed an activation of the right dorsolateral prefrontal and inferior temporal cortex, the left anterior cingulate cortex and a deactivation of the left insula. This suggests that changes in cortical activation related to mania are subcortically driven, involving notably the substantia nigra.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Transtorno Bipolar
/
Substância Negra
/
Estimulação Encefálica Profunda
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Neurol Neurosurg Psychiatry
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
França