Recognition of DNA with assembly of minor groove binders mediated by metal complexation.
Nucleic Acids Symp Ser (Oxf)
; (50): 161-2, 2006.
Article
em En
| MEDLINE
| ID: mdl-17150867
ABSTRACT
Genome-targeting molecules would have broad application as probes in genomic study. We recently developed the ligands (Bpy-H) connecting the Hoechst33258 skeleton for DNA binding and 2,2'-bipyridine for Cu(2+) complexation. It was shown that L-Bpy-H with a long linker exhibited Cu(2+)-mediated assembly on the DNA template having two A(3)T(3) sites in a ratio of 121 DNA-ligand-Cu(2+). Binding selectivity depends on the distance between the two A(3)T(3) sites of DNA. In contrast, S-Bpy-H having a short linker tended to form 122 DNA-ligand-Cu(2+) complex.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzimidazóis
/
2,2'-Dipiridil
/
DNA
/
Cobre
Idioma:
En
Revista:
Nucleic Acids Symp Ser (Oxf)
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Japão