Impact of modafinil on prefrontal executive function in schizophrenia.
Am J Psychiatry
; 163(12): 2184-6, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-17151173
ABSTRACT
OBJECTIVE:
The purpose of this study was to investigate the acute effects of modafinil on prefrontal activation and cognitive control of motor activity in people with schizophrenia and prominent negative symptoms.METHOD:
In a crossover design, 12 subjects with schizophrenia were studied twice, receiving either modafinil or placebo prior to functional magnetic resonance imaging (fMRI). Inside the scanner, they performed a task probing cognitive control that required deliberate variation of motor activity in time.RESULTS:
Modafinil administration was associated with significantly greater activation of the dorsolateral prefrontal cortex during fMRI. Its physiological and behavioral effects were correlated. This was most evident in individuals with worse baseline executive function. Focal response to modafinil in the left dorsolateral prefrontal cortex and baseline letter fluency scores predicted most of the variance in the drug's effect on cognitive control.CONCLUSIONS:
Modafinil did not improve cognitive control in all schizophrenia patients. Increased activation in the dorsolateral prefrontal cortex and in neuropsychological performance were observed in patients with suboptimal baseline function.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Psicologia do Esquizofrênico
/
Compostos Benzidrílicos
/
Imageamento por Ressonância Magnética
/
Córtex Pré-Frontal
/
Transtornos Cognitivos
/
Estimulantes do Sistema Nervoso Central
/
Testes Neuropsicológicos
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Am J Psychiatry
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Reino Unido